The $1M ALS Biomarker Prize Has Been Won!
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<table width="100%" border="0" cellspacing="0" cellpadding="0" bgcolor="#FFFFFF"> <tr> <td><span class=default> <!-- <div id="translate-this"><a href="http://translateth.is/" class="translate-this-button">Translate</a></div> <script type="text/javascript" src="http://www.google.com/jsapi"></script> <script type="text/javascript" src="http://x.translateth.is/translate-this.js"></script> <script type="text/javascript"> TranslateThis(); </script> --> <!-- startprint --> <span class=default><p>In October of 2010, Prize4Life closed submissions for the $1M ALS Treatment Prize, which was announced in 2008 and aimed to fill the drug development pipeline with promising therapeutics by encouraging researchers to extend the lives of ALS mouse models by 25%. To date, no compound tested in ALS SOD mouse models under rigorous experimental conditions has demonstrated the ability to extend lifespan in these animals by even 10%. This lack of effect in animals has correlated with a lack of effect in patients and over the past 7 years the ALS community has had to withstand the disappointment of numerous failed clinical trials. While the 25% bar set by Prize4Life was certainly high, this level of efficacy remains the best hope for identifying a new ALS treatment and bringing it to the attention of the drug development community. </p> <p>Thirty-three teams competed for the $1M ALS Treatment Prize - 17 from an industry background, and 16 from academia. Seventeen teams had never before worked in ALS, incentivized by the $1M prize. While several teams submitted strong proposals, our Scientific Advisory Board determined that none had yet met the high bar of expectations our prize criteria had set forth. Prize4Life is currently deliberating whether to relaunch the $1M ALS Treatment Prize or re-focus this prize purse toward a different goal. </p> <p>Many of the teams who competed for this prize are continuing their research with the ongoing support of Prize4Life. The proper design of trial protocols as well as their outcomes are very important, and quality controlled mice from the SOD1 mouse colony originally created in conjunction with this prize is still available to researchers at a deeply-discounted rate. To download a free copy of the manual "Working With ALS Mice", click <a title="" href="http://www.researchals.org/uploaded_files/p4l_jax_sod1manual_20091202_29aPcx.pdf">here</a>.</p> <p>To view specific prize criteria, click <a title="" href="/uploaded_files/09_p4l_als_treatment_prize_final_language_982nSG.pdf">here</a>. </p></span> <!-- stopprint --> </span></td> </tr> </table>
